Preheat your grill or a skillet over medium-high heat.
In a bowl, combine the ground beef with garlic powder, onion powder, salt, and pepper. Mix gently until just combined, then shape into 6 equal patties. Make a small indentation in the center of each patty to help prevent them from puffing up while they cook.
Place the patties on the grill or skillet. Cook for about 3-4 minutes per side for medium rare, adding a slice of cheddar cheese on top during the last minute of cooking to melt.
While the burgers are cooking, slice the slider buns in half and toast them lightly on the grill or a pan until golden.
In a small bowl, mix together mayonnaise, ketchup, and mustard to create a flavorful sauce.
Assemble the sliders by spreading a small amount of sauce on the bottom half of each bun. Add a prepared cheeseburger patty, a layer of shredded lettuce, a slice of tomato, and a few pickle slices. Cap with the top half of the bun.
Serve immediately with a side of fries or a simple salad.